Bempedoic acid and Ezetimibe and simvastatin interaction
Bempedoic acid and Ezetimibe and simvastatin: the Bempedoic acid prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Bempedoic acid (Nexletol) label · effective 2026-06-25
Intervention : Avoid concomitant use of NEXLETOL with simvastatin greater than 20 mg.
Simvastatin: Avoid concomitant use of NEXLETOL with simvastatin greater than 20 mg.
Clinically Important Drug Interactions with NEXLETOL Simvastatin Clinical Impact: Concomitant use of NEXLETOL with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy [see Clinical Pharmacology (12.3) ] .
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.