Benazepril and hydrochlorothiazide and Butalbital, aspirin, and caffeine interaction
Benazepril and hydrochlorothiazide and Butalbital, aspirin, and caffeine: the Benazepril and hydrochlorothiazide prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Benazepril and hydrochlorothiazide (Lotensin HCT) label · effective 2026-02-24
NSAIDs and Cox-2 selective agents: In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including benazepril, may result in deterioration of renal function, including possible acute renal failure.
Monitor renal function periodically in patients receiving benazepril and NSAID therapy.
Alcohol, barbiturates or narcotics: Concomitant administration of thiazide diuretics with alcohol, barbiturates, or narcotics may potentiate orthostatic hypotension.
The antihypertensive effect of benazepril and hydrochlorothiazide may be attenuated by NSAIDs.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.