Benazepril and hydrochlorothiazide and Chlorpromazine interaction
Benazepril and hydrochlorothiazide and Chlorpromazine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Chlorpromazine (Chlorpromazine Hydrochloride) label · effective 2026-02-02
Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines.
Chlorpromazine may counteract the antihypertensive effect of guanethidine and related compounds.
From the Benazepril and hydrochlorothiazide (Lotensin HCT) label · effective 2026-02-24
Drugs that alter gastrointestinal motility: The bioavailability of thiazide-type diuretics may be increased by anticholinergic agents (e.g., atropine, biperiden), apparently due to a decrease in gastrointestinal motility and the stomach emptying rate.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.