Benazepril and hydrochlorothiazide and Lithium interaction
Benazepril and hydrochlorothiazide and Lithium: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Benazepril and hydrochlorothiazide (Lotensin HCT) label · effective 2026-02-24
Lithium: Renal clearance of lithium is reduced by thiazides and increase the risk of lithium toxicity.
Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.
Monitor lithium levels when used concomitantly with Lotensin HCT.
From the Lithium (Lithium Carbonate) label · effective 2026-08-16
• Diuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.
Drugs Having Clinically Important Interactions with Lithium Table 4: Clinically Important Drug Interactions with Lithium Diuretics Clinical Impact: Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations .
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.