Benztropine and Vilazodone interaction

Benztropine and Vilazodone: the Benztropine prescribing label mention this combination without an instruction to avoid it or change the dose.

Minor

Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.

What the FDA labels say

From the Benztropine (BENZTROPINE MESYLATE) label · effective 2026-02-16

Minor

Paralytic ileus, hyperthermia and heat stroke, all of which have sometimes been fatal, have occurred in patients taking anticholinergic-type antiparkinsonism drugs, including benztropine mesylate, in combination with phenothiazines and/or tricyclic antidepressants.

Warningsby drug classView label on DailyMed
Minor

Drug Interactions Antipsychotic drugs such as phenothiazines or haloperidol; tricyclic antidepressants [ see WARNINGS ].

Drug interactionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.