Bexarotene and Levothyroxine interaction
Bexarotene and Levothyroxine: the Bexarotene prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Bexarotene (Targretin) label · effective 2020-04-30
Monitor and replace thyroid hormone if needed.
Hypothyroidism TARGRETIN induces hypothyroidism in about half of all patients treated by causing a reversible reduction in levels of thyroid hormone (total thyroxine [total T4]) and thyroid-stimulating hormone (TSH).
Consider treatment with thyroid hormone supplementation in patients with hypothyroidism.
In the 300 mg/m 2 /day initial dose group, 37% of patients were treated with thyroid hormone replacement.
Obtain baseline thyroid function tests and patients monitor during treatment.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.