Bictegravir, emtricitabine, and tenofovir alafenamide and Phenobarbital, hyoscyamine, atropine, and scopolamine interaction
Bictegravir, emtricitabine, and tenofovir alafenamide and Phenobarbital, hyoscyamine, atropine, and scopolamine: the Bictegravir, emtricitabine, and tenofovir alafenamide prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Bictegravir, emtricitabine, and tenofovir alafenamide (BIXLENVO) label · effective 2026-08-27
Anticonvulsants: carbamazepine oxcarbazepine phenobarbital phenytoin ↓ lenacapavir ↓ bictegravir Concomitant administration with carbamazepine or phenytoin is contraindicated.
Concomitant administration with oxcarbazepine or phenobarbital is not recommended.
Sedatives/Hypnotics: midazolam (oral) triazolam ↑ midazolam (oral) ↑ triazolam Use caution when midazolam or triazolam is concomitantly administered with BIXLENVO.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.