Bismuth subcitrate, metronidazole, and tetracycline and Nafcillin interaction

Bismuth subcitrate, metronidazole, and tetracycline and Nafcillin: the Nafcillin prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Nafcillin label · effective 2024-12-06

Major

Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided.

Drug interactionsnames Bismuth subcitrate, metronidazole, and tetracyclineView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.