Bisoprolol and hydrochlorothiazide and Penicillin G interaction

Bisoprolol and hydrochlorothiazide and Penicillin G: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Bisoprolol and hydrochlorothiazide (bisoprolol fumarate and hydrochlorothiazide) label · effective 2026-08-11

Moderate

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.

Warningsby drug classView label on DailyMed

From the Penicillin G (PENICILLIN G POTASSIUM) label · effective 2026-07-24

Minor

These drugs include: aspirin, phenylbutazone, sulfonamides, indomethacin, thiazide diuretics, furosemide and ethacrynic acid.

Drug interactionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.