Bivalirudin and Levothyroxine and liothyronine interaction
Bivalirudin and Levothyroxine and liothyronine: the Levothyroxine and liothyronine prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Levothyroxine and liothyronine (NP Thyroid 60) label · effective 2026-01-01
Drug Interactions Oral Anticoagulants — Thyroid hormones appear to increase catabolism of vitamin K-dependent clotting factors.
If oral anticoagulants are also being given, compensatory increases in clotting factor synthesis are impaired.
If a patient is truly hypothyroid, it is likely that a reduction in anticoagulant dosage will be required.
No special precautions appear to be necessary when oral anticoagulant therapy is begun in a patient already stabilized on maintenance thyroid replacement therapy.
Hypothyroidism decreases and hyperthyroidism increases the sensitivity to oral anticoagulants.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.