Bortezomib and Mitotane interaction
Bortezomib and Mitotane: the Bortezomib prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Bortezomib (BORUZU) label · effective 2025-07-05
Strong CYP3A4 Inducers: Avoid concomitant use.
Avoid coadministration with strong CYP3A4 inducers.
Effects of Other Drugs on BORUZU Strong CYP3A4 Inducers Coadministration with a strong CYP3A4 inducer decreases the exposure of bortezomib [see Clinical Pharmacology (12.3) ] which may decrease bortezomib efficacy.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.