Bosentan and Olmesartan, amlodipine, and hydrochlorothiazide interaction
Bosentan and Olmesartan, amlodipine, and hydrochlorothiazide: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Olmesartan, amlodipine, and hydrochlorothiazide (Olmesartan medoxomil, amlodipine and hydrochlorothiazide) label · effective 2026-01-05
Blood pressure should be closely monitored when amlodipine is co-administered with CYP3A inducers.
CYP3A Inducers: No information is available on the quantitative effects of CYP3A inducers on amlodipine.
From the Bosentan (Tracleer) label · effective 2025-11-17
Patients required intervention with a diuretic, fluid management, or hospitalization for decompensating heart failure.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.