Brexpiprazole and Clozapine interaction
Brexpiprazole and Clozapine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Brexpiprazole (Rexulti) label · effective 2026-04-23
Strenuous exercise, exposure to extreme heat, dehydration, and anticholinergic medications may contribute to an elevation in core body temperature; use REXULTI with caution in patients who may experience these conditions.
Seizures Like other antipsychotic drugs, REXULTI may cause seizures.
Potential for Cognitive and Motor Impairment REXULTI, like other antipsychotics, may cause somnolence and has the potential to impair judgment, thinking, or motor skills.
From the Clozapine (Clozaril) label · effective 2025-06-06
An increased risk cannot be excluded for CLOZARIL or other antipsychotics or other patient populations.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.