Brexpiprazole and Iloperidone interaction
Brexpiprazole and Iloperidone: both prescribing labels mention this combination without an instruction to avoid it or change the dose.
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Brexpiprazole (Rexulti) label · effective 2026-04-23
Seizures Like other antipsychotic drugs, REXULTI may cause seizures.
Potential for Cognitive and Motor Impairment REXULTI, like other antipsychotics, may cause somnolence and has the potential to impair judgment, thinking, or motor skills.
From the Iloperidone (FANAPT) label · effective 2026-05-06
Seizures Like other antipsychotic drugs, FANAPT may cause seizures.
In the short-term trials, FANAPT was associated with modest levels of prolactin elevation compared to greater prolactin elevations observed with some other antipsychotic agents.
Potential for Cognitive and Motor Impairment FANAPT, like other antipsychotics, may cause somnolence and has the potential to impair judgment, thinking or motor skills.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.