Bupivacaine and epinephrine and Perphenazine interaction
Bupivacaine and epinephrine and Perphenazine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Perphenazine label · effective 2026-08-25
If hypotension develops, epinephrine should not be administered since its action is blocked and partially reversed by perphenazine.
If a vasopressor is needed, norepinephrine may be used.
From the Bupivacaine and epinephrine (Marcaine) label · effective 2026-05-29
Possible early warning signs of central nervous system (CNS) toxicity are restlessness, anxiety, incoherent speech, lightheadedness, numbness and tingling of the mouth and lips, metallic taste, tinnitus, dizziness, blurred vision, tremors, twitching, CNS depression, or drowsiness.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.