Butalbital, aspirin, and caffeine and Fluphenazine interaction

Butalbital, aspirin, and caffeine and Fluphenazine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Fluphenazine (Fluphenazine Hydrochloride) label · effective 2024-11-14

Moderate

Moreover, it should be remembered that reduced amounts of anesthetics or central nervous system depressants may be necessary.

Precautionsby drug classView label on DailyMed

From the Butalbital, aspirin, and caffeine label · effective 2026-05-11

Moderate

Other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.

Drug interactionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.