Butalbital, aspirin, and caffeine and Meloxicam interaction
Butalbital, aspirin, and caffeine and Meloxicam: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Butalbital, aspirin, and caffeine label · effective 2026-05-11
Patients with the syndrome of nasal polyps, angioedema and bronchospastic reactivity to aspirin or other nonsteroidal anti-inflammatory drugs.
From the Meloxicam (QAMZOVA) label · effective 2026-07-16
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Exacerbation of Asthma Related to Aspirin Sensitivity : QAMZOVA is contraindicated in patients with aspirin-sensitive asthma.
Exacerbation of Asthma Related to Aspirin Sensitivity A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs.
Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, QAMZOVA is contraindicated in patients with this form of aspirin sensitivity [ see Contraindications ( 4 ) ].
Avoid administration of more than one NSAID at a time.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.