Cannabidiol (prescription) and Dimenhydrinate interaction
Cannabidiol (prescription) and Dimenhydrinate: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Cannabidiol (prescription) (Epidiolex) label · effective 2026-05-29
Other CNS depressants, including alcohol, could potentiate the somnolence and sedation effect of EPIDIOLEX.
Some subjects in the EPIDIOLEX clinical trials had pruritus, erythema, and angioedema requiring treatment, including corticosteroids and antihistamines.
From the Dimenhydrinate label · effective 2025-01-15
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.