Cannabidiol (prescription) and Everolimus interaction
Cannabidiol (prescription) and Everolimus: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Cannabidiol (prescription) (Epidiolex) label · effective 2026-05-29
• A lower starting dose of orally administered everolimus is recommended.
Orally Administered P-gp Substrates Concomitant use of EPIDIOLEX with orally administered everolimus results in an approximately 2.5‑fold increase in plasma exposures of everolimus [see Clinical Pharmacology ( 12.3 )] .
When initiating EPIDIOLEX in patients taking everolimus, monitor therapeutic drug levels of everolimus and adjust the dosage accordingly.
In patients on a stable dosage of EPIDIOLEX, it is recommended to initiate everolimus at a lower starting dosage and titrate the dose based on therapeutic drug monitoring.
From the Everolimus (Zortress) label · effective 2026-02-12
Cannabidiol Drug Interactions When cannabidiol and Zortress are coadministered, closely monitor for an increase in everolimus blood levels and for adverse reactions suggestive of everolimus toxicity.
A dose reduction of Zortress should be considered as needed when Zortress is coadministered with cannabidiol [see Dosage and Administration (2.3), Drug Interactions (7.13)] .
Therapeutic drug monitoring and dose reduction for Zortress should be considered when Zortress is coadministered with cannabidiol ( 5.22 , 7.13 )
Cannabidiol The blood levels of everolimus may increase upon concomitant use with cannabidiol.
When cannabidiol and Zortress are coadministered, closely monitor for an increase in everolimus blood levels and for adverse reactions suggestive of everolimus toxicity.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.