Cannabidiol (prescription) and Pimavanserin interaction

Cannabidiol (prescription) and Pimavanserin: the Cannabidiol (prescription) prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Cannabidiol (prescription) (Epidiolex) label · effective 2026-05-29

Moderate

Other CNS depressants, including alcohol, could potentiate the somnolence and sedation effect of EPIDIOLEX.

Warnings and precautionsby drug classView label on DailyMed

Moderate

CNS Depressants and Alcohol Concomitant use of EPIDIOLEX with other CNS depressants (including alcohol) may increase the risk of sedation and somnolence [see Warnings and Precautions ( 5.2 )] .

Drug interactionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.