Carbidopa, levodopa, and entacapone and Entacapone interaction
Carbidopa, levodopa, and entacapone and Entacapone: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Entacapone label · effective 2019-03-14
…Metabolized By Catechol-O-Methyltransferase (COMT) When a single 400 mg dose of entacapone was given with intravenous isoprenaline (isoproterenol) and epinephrine without coadministered levodopa and dopa decarboxylase inhibitor, the overall mean maximal changes in heart rate during infusion were about 50% and 80% higher than with placebo, for isoprenaline and epinephrine,…
Falling Asleep During Activities of Daily Living and Somnolence Patients with Parkinson’s disease treated with Entacapone Tablets, which increases plasma levodopa levels, or with levodopa have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living (including the operation of motor vehicles).
Hormone Levels Levodopa is known to depress prolactin secretion and increase growth hormone levels.
Treatment with entacapone coadministered with levodopa and dopa decarboxylase inhibitor does not change these effects.
More than 600 patients with Parkinson’s disease in clinical studies have used selegiline in combination with entacapone and levodopa and dopa decarboxylase inhibitor.
From the Carbidopa, levodopa, and entacapone (Carbidopa, Levodopa and Entacapone) label · effective 2026-04-08
Because patients may not recognize these behaviors as abnormal it is important for prescribers to specifically ask patients or their caregivers about the development of new or increased gambling urges, sexual urges, uncontrolled spending or other urges while being treated with entacapone.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.