Cefepime and Gentamicin interaction
Cefepime and Gentamicin: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Gentamicin (Gentamicin Sulfate in Sodium Chloride) label · effective 2023-01-26
Increased nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins.
From the Cefepime (CEFEPIME HYDROCHLORIDE AND DEXTROSE) label · effective 2026-04-07
Aminoglycosides: Increased potential of nephrotoxicity and ototoxicity.
Aminoglycosides Monitor renal function if aminoglycosides are to be administered with Cefepime for Injection and Dextrose Injection because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibacterials.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.