Ceftriaxone and Phytonadione (vitamin K1) interaction
Ceftriaxone and Phytonadione (vitamin K1): the Ceftriaxone prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Ceftriaxone (CEFTRIAXONE AND DEXTROSE) label · effective 2022-01-13
Patients with impaired vitamin K synthesis or low vitamin K stores (e.g., chronic hepatic disease and malnutrition) may require monitoring of prothrombin time during Ceftriaxone for Injection and Dextrose Injection treatment.
Vitamin K administration (10 mg weekly) may be necessary if the prothrombin time is prolonged before or during therapy.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.