Chlordiazepoxide and clidinium and Doxylamine interaction

Chlordiazepoxide and clidinium and Doxylamine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Doxylamine (nighttime sleep aid) label · effective 2026-04-15

Major

…breathing problem such as emphysema or chronic bronchitis • glaucoma • trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are taking • a sedative or any other sleep-aid • tranquilizers • any other antihistamines • any other drugs When using this product • avoid alcoholic beverages • do not drive a motor vehicle or operate…

Warningsby drug classView label on DailyMed

From the Chlordiazepoxide and clidinium (Librax) label · effective 2023-01-13

Moderate

Effects on the Ability to Drive or Operate Machinery As in the case of other preparations containing CNS-acting drugs, patients receiving Librax should be cautioned about possible combined effects with opioids, alcohol and other CNS depressants.

Warningsby drug classView label on DailyMed
Minor

As with other anticholinergic drugs, clidinium may cause suppression of lactation.

Drug interactionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.