Chlordiazepoxide and Droperidol interaction

Chlordiazepoxide and Droperidol: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Droperidol label · effective 2023-03-20

Major

Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates.

Boxed warningby drug classView label on DailyMed
Moderate

CNS Depressant Drugs: Other CNS depressant drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics) have additive or potentiating effects with droperidol.

Drug interactionsby drug classView label on DailyMed
Moderate

Following the administration of droperidol, the dose of other CNS depressant drugs should be reduced.

Drug interactionsby drug classView label on DailyMed
Minor

As with other CNS depressant drugs, patients who have received droperidol should have appropriate surveillance.

Warningsby drug classView label on DailyMed

From the Chlordiazepoxide (CHLORDIAZEPOXIDE HYDROCHLORIDE) label · effective 2023-02-07

Moderate

The concomitant use of alcohol or other central nervous system depressants may have an additive effect.

Warningsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.