Chlorpromazine and Valproic acid interaction
Chlorpromazine and Valproic acid: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Chlorpromazine (Chlorpromazine Hydrochloride) label · effective 2026-02-02
Therefore, dosage of anticonvulsants, including barbiturates, should not be reduced if chlorpromazine is started.
Chlorpromazine may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary.
Note: Chlorpromazine does not intensify the anticonvulsant action of barbiturates.
Potentiation of anticonvulsant effects does not occur.
From the Valproic acid label · effective 2024-05-02
Chlorpromazine A study involving the administration of 100 to 300 mg/day of chlorpromazine to schizophrenic patients already receiving valproate (200 mg BID) revealed a 15% increase in trough plasma levels of valproate.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.