Cimetidine and Oxymorphone interaction
Cimetidine and Oxymorphone: the Oxymorphone prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Oxymorphone (Oxymorphone hydrochloride) label · effective 2026-01-15
Cimetidine Clinical Impact: Cimetidine can potentiate opioid-induced respiratory depression.
Intervention: Evaluate patients for respiratory depression when Oxymorphone Hydrochloride Extended-Release Tablets and cimetidine are used concurrently.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.