Clarithromycin and Zidovudine interaction
Clarithromycin and Zidovudine: the Clarithromycin prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Clarithromycin label · effective 2026-01-01
Zidovudine Zidovudine: Simultaneous oral administration of clarithromycin immediate-release tablets and zidovudine to HIV-infected adult patients may result in decreased steady-state zidovudine concentrations.
Administration of clarithromycin and zidovudine should be separated by at least two hours [see Pharmacokinetics ( 12.3 )] .
The impact of co-administration of clarithromycin extended-release tablets or granules and zidovudine has not been evaluated.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.