Clonazepam and Guanfacine interaction
Clonazepam and Guanfacine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Clonazepam (Klonopin) label · effective 2025-12-01
They should also be warned about the concomitant use of alcohol or other CNS-depressant drugs during Klonopin therapy (see PRECAUTIONS: Drug Interactions and PRECAUTIONS: Information for Patients ).
From the Guanfacine (Intuniv) label · effective 2025-06-23
Consider the potential for additive sedative effects with CNS depressant drugs.
Before using INTUNIV with other centrally active depressants, consider the potential for additive sedative effects.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.