Clotrimazole and Rilpivirine interaction
Clotrimazole and Rilpivirine: the Rilpivirine prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Rilpivirine (EDURANT) label · effective 2025-08-28
Azole Antifungal Agents: fluconazole itraconazole ketoconazole This interaction study has been performed with a dose higher than the recommended dose for EDURANT assessing the maximal effect on the coadministered drug.
The dosing recommendation is applicable to the recommended doses of EDURANT once daily. posaconazole voriconazole ↑ rilpivirine ↓ ketoconazole Concomitant use of EDURANT or EDURANT PED with azole antifungal agents may cause an increase in the plasma concentrations of rilpivirine (inhibition of CYP3A enzymes).
No rilpivirine dose adjustment is required when EDURANT or EDURANT PED is coadministered with azole antifungal agents.
Clinically monitor for breakthrough fungal infections when azole antifungals are coadministered with EDURANT or EDURANT PED.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.