Clotrimazole and Voriconazole interaction

Clotrimazole and Voriconazole: the Voriconazole prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Voriconazole label · effective 2026-06-02

Major

There is no information regarding cross-sensitivity between voriconazole and other azole antifungal agents.

Contraindicationsby drug classView label on DailyMed
Major

Refer to the prescribing information for other azole antifungal agents.

Contraindicationsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.