Clozapine and Pyridostigmine interaction
Clozapine and Pyridostigmine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Clozapine (Clozaril) label · effective 2025-06-06
Recurrence of Psychosis and Cholinergic Rebound after Abrupt Discontinuation of CLOZARIL If abrupt discontinuation of CLOZARIL is necessary (because of severe neutropenia or another medical condition, for example) [see Dosage and Administration ( 2.5 ), Warnings and Precautions ( 5.1 )] , monitor carefully for the recurrence of psychotic symptoms and adverse…
From the Pyridostigmine (Pyridostigmine bromide) label · effective 2026-05-13
Use with caution in persons with increased risk of anticholinergic reactions, such as persons with bronchial asthma, chronic obstructive pulmonary disease, bradycardia, cardiac arrhythmias, beta blocker treatment (increased risk of anticholinergic reactions).
Increased Risk of Anticholinergic Adverse Reactions in Individuals with Certain Conditions Pulmonary Conditions Drugs that increase cholinergic activity, including pyridostigmine bromide, should be used with caution in persons with bronchial asthma or chronic obstructive pulmonary disease.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.