Cyclosporine and Ezetimibe interaction
Cyclosporine and Ezetimibe: the Ezetimibe prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Ezetimibe (Zetia) label · effective 2025-11-25
Table 3: Clinically Important Drug Interactions with ZETIA Cyclosporine Clinical Impact: Concomitant use of ZETIA and cyclosporine increases ezetimibe and cyclosporine concentrations.
Intervention: Monitor cyclosporine concentrations in patients receiving ZETIA and cyclosporine.
In patients treated with cyclosporine, weigh the potential effects of the increased exposure to ezetimibe from concomitant use against the benefits of alterations in lipid levels provided by ZETIA.
Cyclosporine: Combination increases exposure of ZETIA and cyclosporine.
Cyclosporine concentrations should be monitored in patients taking ZETIA concomitantly.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.