Dantrolene and Verapamil interaction
Dantrolene and Verapamil: the Dantrolene prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Dantrolene (RYANODEX dantrolene sodium) label · effective 2024-10-30
The concomitant use of RYANODEX and calcium channel blockers is not recommended during the treatment of malignant hyperthermia.
Calcium Channel Blockers : Concomitant use can cause cardiovascular collapse in association with marked hyperkalemia ( 7.1 )
Calcium Channel Blockers Cardiovascular collapse in association with marked hyperkalemia has been reported in patients receiving dantrolene in combination with calcium channel blockers.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.