Darunavir and cobicistat and Methazolamide interaction
Darunavir and cobicistat and Methazolamide: the Darunavir and cobicistat prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Darunavir and cobicistat (PREZCOBIX) label · effective 2026-02-01
Monitor in patients with a known sulfonamide allergy.
Monitor patients with a known sulfonamide allergy after initiating PREZCOBIX or PREZCOBIX PED.
Sulfa Allergy Darunavir contains a sulfonamide moiety.
In clinical studies with darunavir co-administered with ritonavir, the incidence and severity of rash were similar in participants with or without a history of sulfonamide allergy.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.