Dasatinib and Omeprazole and sodium bicarbonate interaction
Dasatinib and Omeprazole and sodium bicarbonate: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Dasatinib (PHYRAGO) label · effective 2025-08-23
Antacids Avoid concomitant use of PHYRAGO with antacids.
If concomitant use of an antacid cannot be avoided, administer the antacid at least 2 hours prior to or 2 hours after the dose of PHYRAGO [see Dosage and Administration ( 2.3 )] .
Concomitant use with antacids decreases dasatinib plasma concentrations [see Clinical Pharmacology ( 12.3 )] , which may reduce PHYRAGO efficacy.
From the Omeprazole and sodium bicarbonate (Konvomep) label · effective 2025-12-16
Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Omeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.