Interaction Checker

Desogestrel and ethinyl estradiol and Estradiol and dienogest interaction

Desogestrel and ethinyl estradiol and Estradiol and dienogest: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Desogestrel and ethinyl estradiol label · effective 2026-06-24

Major

…surgery with prolonged immobilization • Current diagnosis of, or history of, breast cancer, which may be hormone-sensitive • Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia • Undiagnosed abnormal genital bleeding • Cholestatic jaundice of pregnancy or jaundice with prior pill use • Acute or chronic hepatocellular disease with…

Contraindicationsby drug classView label on DailyMed
Moderate

Effects of Other Drugs on Combined Hormonal Contraceptives Substances decreasing the plasma concentrations of COCs and potentially diminishing the efficacy of COCs: Drugs or herbal products that induce certain enzymes, including cytochrome P450 3A4 (CYP3A4), may decrease the plasma concentrations of COCs and potentially diminish the effectiveness of CHCs or increase…

Drug interactionsby drug classView label on DailyMed
Minor

If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy.

Warningsby drug classView label on DailyMed

From the Estradiol and dienogest (Natazia) label · effective 2024-06-26

Minor

Effects of Combined Oral Contraceptives on Other Drugs COCs containing ethinyl estradiol may inhibit the metabolism of other compounds.

Drug interactionsnames Desogestrel and ethinyl estradiolView label on DailyMed
Minor

Effects of Other Drugs on Combined Oral Contraceptives Substances diminishing the efficacy of COCs: Dienogest is a substrate of CYP3A4.

Drug interactionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.