Deutetrabenazine and Valbenazine interaction
Deutetrabenazine and Valbenazine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Deutetrabenazine (Austedo) label · effective 2025-02-28
Taking tetrabenazine or valbenazine [see Drug Interactions ( 7.6 )] .
Taking reserpine, MAOIs, tetrabenazine, or valbenazine ( 4 , 7.2 , 7.3 , 7.6 )
Concomitant Tetrabenazine or Valbenazine AUSTEDO XR and AUSTEDO are contraindicated in patients currently taking tetrabenazine or valbenazine.
Parkinsonism has also been observed with other VMAT2 inhibitors.
From the Valbenazine (INGREZZA) label · effective 2026-04-17
Parkinsonism has also been observed with other VMAT2 inhibitors.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.