Dexamethasone and Flibanserin interaction
Dexamethasone and Flibanserin: the Flibanserin prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Flibanserin (ADDYI) label · effective 2025-12-22
Preventing or Managing DI The concomitant use of ADDYI with CYP3A4 inducers is not recommended.
• CYP3A4 Inducers : Use of ADDYI not recommended; flibanserin concentrations substantially reduced (7)
John's Wort Clinical Implications The concomitant use of ADDYI with CYP3A4 inducers substantially decreases flibanserin exposure compared to the use of ADDYI alone.
CYP3A4 Inducers Examples Carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapetine, St.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.