Dexamethasone and Glycerol phenylbutyrate interaction
Dexamethasone and Glycerol phenylbutyrate: the Glycerol phenylbutyrate prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Glycerol phenylbutyrate label · effective 2025-06-30
Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely.
Potential for Other Drugs to Affect Ammonia Corticosteroids Use of corticosteroids may cause the breakdown of body protein and increase plasma ammonia levels.
Monitor ammonia levels closely when corticosteroids and glycerol phenylbutyrate are used concomitantly.
Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.