Dexamethasone and Orphenadrine, aspirin, and caffeine interaction
Dexamethasone and Orphenadrine, aspirin, and caffeine: the Dexamethasone prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Dexamethasone (Hemady) label · effective 2026-01-09
Monitor for toxicity when aspirin is used in conjunction with HEMADY in hypoprothrombinemia.
Nonsteroidal Anti-Inflammatory Agents (NSAIDS) Concomitant use of aspirin (or other nonsteroidal anti-inflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects [see Warnings and Precautions ( 5.7 ) and Adverse Reactions ( 6 )] .
The clearance of salicylates may be increased with concurrent use of corticosteroids.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.