Dextromethorphan and quinidine and Mexiletine interaction

Dextromethorphan and quinidine and Mexiletine: the Mexiletine prescribing label mentions this combination without an instruction to avoid it or change the dose.

Minor

Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.

What the FDA labels say

From the Mexiletine (Mexiletine Hydrochloride) label · effective 2026-01-15

Minor

A variety of antiarrhythmics such as quinidine or propranolol were also added, sometimes with improved control of ventricular ectopy.

Drug interactionsnames Dextromethorphan and quinidineView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.