Diclofenac and Meloxicam interaction
Diclofenac and Meloxicam: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Diclofenac (Diclofenac Potassium) label · effective 2025-01-21
Diclofenac Potassium is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to diclofenac or any components of the drug product [see Warnings and Precautions (5.7 , 5.9 )] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs (4)
Avoid administration of more than one NSAID at a time.
Exacerbation of Asthma Related to Aspirin Sensitivity A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs.
Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, Diclofenac Potassium is contraindicated in patients with this form of aspirin sensitivity [see Contraindications (4) ].
From the Meloxicam (QAMZOVA) label · effective 2026-07-16
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Avoid administration of more than one NSAID at a time.
Exacerbation of Asthma Related to Aspirin Sensitivity A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs.
Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, QAMZOVA is contraindicated in patients with this form of aspirin sensitivity [ see Contraindications ( 4 ) ].
Intervention: The concomitant use of meloxicam with other NSAIDs or salicylates is not recommended.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.