Difenoxin and atropine and Remifentanil interaction
Difenoxin and atropine and Remifentanil: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Difenoxin and atropine (Motofen) label · effective 2026-03-23
MOTOFEN ® may potentiate the action of barbiturates, tranquilizers, narcotics, and alcohol.
From the Remifentanil (Ultiva) label · effective 2025-12-08
Bradycardia Bradycardia has been reported with ULTIVA and is responsive to ephedrine or anticholinergic drugs, such as atropine and glycopyrrolate.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.