Dimethyl fumarate and Natalizumab interaction

Dimethyl fumarate and Natalizumab: the Dimethyl fumarate prescribing label mentions this combination without an instruction to avoid it or change the dose.

Minor

Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.

What the FDA labels say

From the Dimethyl fumarate (TECFIDERA) label · effective 2025-06-04

Minor

The patient had no other identified systemic medical conditions resulting in compromised immune system function and had not previously been treated with natalizumab, which has a known association with PML.

Warnings and precautionsnames NatalizumabView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.