Diphenhydramine and Lidocaine and prilocaine interaction
Diphenhydramine and Lidocaine and prilocaine: the Diphenhydramine prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Diphenhydramine label · effective 2026-03-05
Use as a Local Anesthetic Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.