Diphenhydramine and Lisinopril interaction

Diphenhydramine and Lisinopril: the Lisinopril prescribing label mention this combination without an instruction to avoid it or change the dose.

Minor

Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.

What the FDA labels say

From the Lisinopril (Zestril) label · effective 2025-01-02

Minor

Symptoms have not been relieved by antihistamines in these situations.

Warnings and precautionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.