Dofetilide and Prochlorperazine interaction
Dofetilide and Prochlorperazine: the Dofetilide prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Dofetilide label · effective 2026-04-24
In addition, other known inhibitors of the renal cation transport system such as prochlorperazine, dolutegravir and megestrol should not be used in patients on dofetilide.
…affect the pharmacokinetics of dofetilide such as cimetidine (see CONTRAINDICATIONS ), trimethoprim alone or in combination with sulfamethoxazole (see WARNINGS, CONTRAINDICATIONS ), prochlorperazine (see WARNINGS, CONTRAINDICATIONS ), megestrol (see WARNINGS, CONTRAINDICATIONS ), ketoconazole (see WARNINGS, CONTRAINDICATIONS ), dolutegravir (see CONTRAINDICATIONS…
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.