Donepezil and Pilocarpine interaction
Donepezil and Pilocarpine: the Donepezil prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Donepezil (Aricept) label · effective 2021-12-30
Peptic Ulcer Disease and GI Bleeding Through their primary action, cholinesterase inhibitors may be expected to increase gastric acid secretion due to increased cholinergic activity.
Cholinomimetics may cause bladder outflow obstructions ( 5.6 )
Cholinomimetics are believed to have some potential to cause generalized convulsions ( 5.7 )
Genitourinary Conditions Although not observed in clinical trials of ARICEPT, cholinomimetics may cause bladder outflow obstruction.
Neurological Conditions: Seizures Cholinomimetics are believed to have some potential to cause generalized convulsions.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.