Doxazosin and Indomethacin interaction
Doxazosin and Indomethacin: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Indomethacin (Indocin) label · effective 2024-12-16
Monitor patients to assure diuretic efficacy including antihypertensive effects ( 7 )
Hypertension : Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs.
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).
During concomitant use of INDOCIN with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects.
ACE Iinhibitors, Angiotensin Receptor Blockers (ARB), or Beta-Blockers : Concomitant use with INDOCIN may diminish the antihypertensive effect of these drugs.
From the Doxazosin (Doxazosin mesylate) label · effective 2025-11-24
In vitro data in human plasma indicate that Doxazosin has no effect on protein binding of digoxin, warfarin, phenytoin, or indomethacin.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.